Center of Cellular Nanoanalytics Osnabrück

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Selected Publications


Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex

Gao J, Kurre R, Rose J, Walter S, Fröhlich F, Piehler J, Reggiori F, Ungermann C
EMBO Rep., (2020) Oct 7:e50733

TORC1 Determines Fab1 Lipid Kinase Function at Signaling Endosomes and Vacuoles

Chen Z, Malia PC, Hatakeyama R, Nicastro R, Hu Z, Péli-Gulli MP, Gao J, Nishimura T, Eskes E, Stefan CJ, Winderickx J, Dengjel J, De Virgilio C, Ungermann C
Curr Biol., (2020) 30:S0960-9822(20)31530-X

Magnetic and Electronic Properties of Highly Mn-Doped β-NaGdF\(_{4}\) and β-NaEuF\(_{4}\) Nanoparticles with a Narrow Size Distribution

Schneider L, Wehmeier J, Wiedwald U, Rodewald J, Galakhov VR, Udintseva MS, Mesilov V, Radu F, Luo C, Klare JP, Steinhoff H-J, Haase M, Kuepper K
J. Phys. Chem. C, (2020) 124, 33, 18194–18202

Size-Controlled Growth of β-NaGdF4 and β-NaGdF\(_{4}\):Yb,Er Nanocrystals: The Influence of the Surface Area of NaF on the Nucleation of the β-Phase

Czerny J, Heil F, Egbers CJ, Haase M
Chemistry of Materials, (2020) 32 (13), 5691-5699

LiYF\(_{4}\):Yb/LiYF\(_{4}\): and LiYF\(_{4}\)::Yb,Er/LiYF\(_{4}\): core/shell nanocrystals with luminescence decay times similar to YLF laser crystals and the upconversion quantum yield of the Yb,Er doped nanocrystals

Carl F, Birk L, Grauel B, Pons M, Würth C, Resch-Genger U, Haase M
Nano Research, (2020)

Time‐Resolved Nonlinear Diffuse fs‐Pulse Reflectometry Using Lithium Niobate Nanoparticles with Two Pulses of Different Colors

Kijatkin C, Bourdon B, Klenen J, Kocsor L, Szaller Z, Imlau M
Adv. Photonics Res., (2020) Sep 29

The role of cations in hydrothermal synthesis of nonlinear optical sodium niobate nanocrystals

Kohlenbach ND, Kijatkin C, König M, Haase M, Imlau M, Kömpe K
Nanoscale, (2020) Sep 15

Dual-color 3D-dSTORM colocalization and quantification of ROXY1 and RNAPII variants throughout the transcription cycle in root meristem nuclei

Maß L, Holtmannspötter M, Zachgo S
Plant J ., (2020) Sep 8

A conserved and regulated mechanism drives endosomal Rab transition

Langemeyer L, Borchers AC, Herrmann E, Füllbrunn N, Han Y, Perz A, Auffarth K, Kümmel D, Ungermann C
Elife., (2020) 9:e56090

AP‐3 vesicle uncoating occurs after HOPS‐dependent vacuole tethering

Schoppe J, Mari M, Yavavli E, Auffarth K, Cabrera M, Walter S, Fröhlich F, Ungermann C
EMBO J., (2020) Aug 25:e105117

Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo

Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC
Cell Stem Cell., (2020) S1934-5909(20)30358-1

In cellulo protein semi‐synthesis from endogenous and exogenous fragments using the ultra‐fast split Gp41‐1 intein

Bhagawati M, Hoffmann S, Höffgen KS, Piehler J, Busch K, Mootz HD
Angew Chem Int Ed Engl., (2020) Aug 10

In cell Gd\(^{3+}\)-based site-directed spin labeling and EPR spectroscopy of eGFP

Kucher S, Korneev S, Klare JP, Klose D, Steinhoff HJ
Phys Chem Chem Phys., (2020) 22(24):13358-13362

Lipid dynamics in nanoparticles formed by maleic acid-containing copolymers: EPR spectroscopy and molecular dynamics simulations

Colbasevici A, Voskoboynikova N, Orekhov PS, Bozdaganyan ME, Karlova MG, Sokolova OS, Klare JP, Mulkidjanian AY, Shaitan KV, Steinhoff HJ
Biochim Biophys Acta Biomembr., (2020) 1862(5):183207

Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor

Ponsford AH, Ryan TA, Raimondi A, Cocucci E, Wycislo SA, Fröhlich F, Swan LE, Stagi M
Autophagy., (2020) Jun 9:1-19

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae

Esch BM, Limar S, Bogdanowski A, Gournas C, More T, Sundag C, Walter S, Heinisch JJ, Ejsing CS, André B, Fröhlich F
PLoS Genet., (2020) 16(8):e1008745

A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function

Dehnen L, Janz M, Verma JK, Psathaki OE, Langemeyer L, Fröhlich F, Heinisch JJ, Meyer H, Ungermann C, Paululat A
Journal of Cell Science, (2020) 4133(13):jcs247080

A trafficome-wide RNAi screen reveals deployment of early and late secretory host proteins and the entire late endo-/lysosomal vesicle fusion machinery by intracellular Salmonella

Kehl A, Göser V, Reuter T, Liss V, Franke M , John C, Richter CP, Deiwick J, Hensel M
PLoS Pathog., (2020) 16(7):e1008220

The spatio-temporal organization of mitochondrial F\(_{1}\)F\(_{0}\)ATP synthase in cristae depends on its activity mode

Salewskij K, Rieger B, Hager F, Arroum T, Duwe P, Villalta J, Colgiati S, Richter CP, Psathaki OE, Enriquez JA, Dellmann T, Busch KB
Biochim Biophys Acta Bioenerg., (2020) 1861(1):148091

Novel Fluorescent Mitochondria-Targeted Probe MitoCLox Reports Lipid Peroxidation in Response to Oxidative Stress In Vivo

Lyamzaev KG, Panteleeva AA, Karpukhina AA, Galkin II, Popova EN, Pletjushkina OY, Rieger B, Busch KB, Mulkidjanian AY, Chernyak BV
Oxid Med Cell Longev., (2020) 3631272

Self-assembly of robust gold nanoparticle monolayer architectures for quantitative protein interaction analysis by LSPR spectroscopy

Flesch J, Kappen M, Drees C, You C, Piehler J
Analytical and Bioanalytical Chemistr., (2020) 412:3413–3422

Type I IFN is siloed in endosomes

Altman JB, Taft J, Wedeking T, Gruber CN, Holtmannspötter M, Piehler J, and Bogunovic D,
PNAS, (2020) 30, 17510-17512

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD , Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, Vattulainen I, Hitchcock IS, Piehler J
Science, 367(6478), 643-652 (2020)


Close-packed silane nanodot arrays by capillary nanostamping coupled with heterocyclic silane ring opening

Philippi M, You C, Richter CP, Schmidt M, Thien J, Liße D, Wollschlager J, Piehler J and Steinhart M
RSC Adv., 2019, 9, 24742

Blocks in Tricarboxylic Acid Cycle of Salmonella enterica Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction

Noster J, Hansmeier N, Persicke M, Chao TC, Kurre R, Popp J, Liss V, Reuter T, Hensel M
mSphere., (2019) 4(6):e00796-19

MitoCLox: A Novel Mitochondria-Targeted Fluorescent Probe for Tracing Lipid Peroxidation

Konstantin G, Lyamzaev KG, Sumbatyan NV, Nesterenko AM, Kholina EG, Voskoboynikova N, Steinhoff H-J, Mulkidjanian AY
Oxid Med Cell Longev, (2019) 9710208

ESEEM Reveals Bound Substrate Histidine in the ABC Transporter HisQMP\(_2\)

Isaev N, Heuveling J, Ivanisenko N, Schneider E, Steinhoff HJ
Applied Magnetic Resonance, 1-11 (2019)

Conformational dynamics of sensory rhodopsin II in nanolipoprotein and styrene-maleic acid lipid particles

Mosslehy W, Voskoboynikova N, Colbasevici A, Ricke A, Klose D, Klare JP, Mulkidzhanyan AY, Steinhoff HJ
Photochem Photobiol. (2019)

Proton leakage across lipid bilayers: Oxygen atoms of phospholipid ester linkers align water molecules into transmembrane water wires

Bozdaganyan ME, Lokhmatikov AV, Voskoboynikova N, Cherepanov DA, Steinhoff HJ, Shaitan KV, Mulkidjanian AY
BBA-Bioenergetics 1860(6), 439-451 (2019)

Styrene/Maleic Acid Copolymers Form SMALPs by Pulling Lipid Patches out of the Lipid Bilayer

Orekhov PS, Bozdaganyan ME, Voskoboynikova N, Mulkidjanian AY, Steinhoff HJ, Shaitan KV
Langmuir 35(10), 3748-3758 (2019)

Detergent-free solubilization of human Kv channels expressed in mammalian cells

Karlova MG, Voskoboynikova N, Gluhov GS, Abramochkin D, Malak OA, Mulkidzhanyan A, Loussouarn G, Steinhoff HJ, Shaitan KV, Sokolova OS
Chem Phys Lipids 219 (2019)

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Kol M, Williams B, Toombs-Ruane H, Franquelim HG, Korneev S, Schroeer C, Schwille P, Trauner D, Holthuis JC, Frank JA
Elife, 8:e43230 (2019)

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

Pekkinen M, Terhal PA, Botto LD, Henning P, Mäkitie RE, Roschger P, Jain A, Kol M, Kjellberg MA, Paschalis EP, van Gassen K, Murray M, Bayrak-Toydemir P, Magnusson MK, Jans J, Kausar M, Carey JC, Somerharju P, Lerner UH, Olkkonen VM, Klaushofer K, Holthuis JC, Mäkitie O
JCI Insight, 4(7):e126180 (2019)

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Dadsena S, Bockelmann S, Mina JGM, Hassan DG, Korneev S, Razzera G, Jahn H, Niekamp P, Müller D, Schneider M, Tafesse FG, Marrink SJ, Melo MN, Holthuis JCM
Nat Commun, 10(1), 1832 (2019)

A systematic approach to identify recycling endocytic cargo depending on the GARP complex

Eising S, Thiele L, Fröhlich F
eLife 8:e42837 (2019)


Drosophila pericardial nephrocyte ultrastructure changes during ageing

Psathaki OE, Dehnen L, Hartley PS, Paululat A
Mech Ageing Dev., (2018) 173:9-20

Multi-color Localization Microscopy of Single Membrane Proteins in Organelles of Live Mammalian Cells

Appelhans T, Beinlich FRM, Richter CP, Kurre R, Busch KB
J Vis Exp., (2018) 136:57690

Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules

Niewidok B, Igaev M, Pereira da Graca A, Strassner A, Lenzen C, Richter CP, Piehler J, Kurre R, Brandt R
J Cell Biol, 217, 1303-1318 (2018)

Stable and selective self-assembly of α-lipoic acid on Ge(001) for biomolecule immobilization

Kazmierczak M, Flesch J, Mitzloff J, Capellini G, Klesse WM, Skibitzki O, You C, Bettenhausen M, Witzigmann B, Piehler J, Schroeder T, Guha S
Journal of Applied Physics, 123, 175305 (2018)

Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells

Etoc F, Balloul E, Vicario C, Normanno D, Liße D, Sittner A, Piehler J, Dahan M, Coppey M
Nature materials, 17, 740-746 (2018)

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Chavent M, Duncan AL, Rassam P, Birkholz O, Hélie J, Reddy T, Beliaev D, Hambly B, Piehler J, Kleanthous C, Sansom MSP
Nat Commun, 9, 2846 (2018)

Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials

Birkholz O, Burns JR, Richter CP, Psathaki OE, Howorka S, Piehler J
Nat Commun, 9, 1521 (2018)

Germanium Plasmon Enhanced Resonators for Label-Free Terahertz Protein Sensing

Bettenhausen M, Römer F, Witzigmann B, Flesch J, Kurre R, Korneev S, Piehler J, You C, Kazmierczak M, Guha S, Capellini G, Schröder T
Frequenz, 72, 113-122 (2018)

Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis

Bartoschik T, Galinec S, Kleusch C, Walkiewicz K, Breitsprecher D, Weigert S, Muller YA, You C, Piehler J, Vercruysse T, Daelemans D, Tschammer N
Scientific reports, 8, 4977 (2018)

A search for ceramide binding proteins using bifunctional lipid analogues yields CERT-related protein StarD7

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Müller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, and Holthuis JC
J. Lipid. Res., 59, 515-530 (2018)

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

Kunduri G, Turner-Evans D, Konya Y, Izumi Y, Nagashima K, Lockett S, Holthuis J, Bamba T, Acharya U, Acharya JK
Proc. Natl. Acad. Sci. USA 115, E8919-E8928 (2018)

Colloidal Crystals of NaYF4 Upconversion Nanocrystals Studied by Small-Angle X-Ray Scattering (SAXS)

Homann C, Bolze J, Haase M
Part. Part. Syst. Charact. 1800391 (2018)

Colloidal LaPO4:Gd\(^{3+}\) nanocrystals: X-ray induced single line UV emission

Espinoza S, Juestel T, Haase M
Nanoscale 10, 22533-22540 (2018)

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO4:Pr\(^{3+}\)

Espinoza S, Volhard MF, Kätker H, Jenneboer H, Uckelmann A, Haase M, Müller M , Purschke M, Jüstel T
Part. Part. Syst. Charact. 1800282 (2018)

NaYF4:Yb,Er/NaYF4 core/shell nanocrystals with high upconversion luminescence quantum yield

Homann C, Krukewitt L, Frenzel F, Grauel B, Würth C , Resch-Genger U, Haase M
Angew. Chem. Int. Ed. 57, 8765–8769 (2018), DOI
Angew.Chem. 130, 8901–8905 (2018), DOI

Holographic performance of silicon polymer films based on photoswitchable molecules

Bourdon B, Bock S, Kijatkin C, Shumelyuk A, Imlau M
Optical Material Express 8(7), 1951-1967 (2018)

Nonlinear Optical Potassium Niobate Nanocrystals as Harmonic Markers: The Role of Precursors and Stoichiometry in Hydrothermal Synthesis

Wang Z, Kijatkin C, Urban A, Haase M, Imlau M and Kömpe K
Nanoscale, 10, 10713-10720 (2018)


Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, Piehler J
Nat Commun, 8, 15976 (2017)

Magnetic control of cellular processes using biofunctional nanoparticles

Monzel C, Vicario C, Piehler J, Coppey M, Dahan M
Chemical science, 8, 7330-7338 (2017)

Engineered Ferritin for Magnetogenetic Manipulation of Proteins and Organelles Inside Living Cells

Liße D, Monzel C, Vicario C, Manzi J, Maurin I, Coppey M, Piehler J, Dahan M
Advanced materials, 29, 1700189 (2017)

Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling

Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC
Nature, 545, 234-237 (2017)

Binding of interferon reduces the force of unfolding for interferon receptor 1

Chuartzman SG, Nevo R, Waichman S, Shental D, Piehler J, Levy Y, Reich Z, Kapon R
PLoS One, 12, e0175413 (2017)

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Arimoto KI, Löchte S, Stoner SA, Burkart C, Zhang Y, Miyauchi S, Wilmes S, Fan JB, Heinisch JJ, Li Z, Yan M, Pellegrini S, Colland F, Piehler J, Zhang DE
Nature structural & molecular biology, 24, 279-289 (2017)

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

Cabukusta B, Kol M, Kneller L, Hilderink A, Bickert A, Mina JG, Korneev S, Holthuis JC
Sci. Rep. 7, 41290 (2017)

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

Jain A, Beutel O, Ebell K, Korneev S, and Holthuis JC
J. Cell Sci. 130, 360-371 (2017)

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JGM, Somerharju P, Korneev S, Tafesse FG, and Holthuis JC
J. Lipid Res. 58, 962-973 (2017)

Nonlinear Diffuse fs-Pulse Reflectometry of Harmonic Upconversion Nanoparticles

Kijatkin C, Eggert J, Bock S, Berben D, Oláh L, Szaller Z, Kis Z and Imlau M
Photonics, 4(1), 11 (2017)


Monitoring Changes in the Oligomeric State of a Candidate Endoplasmic Reticulum (ER) Ceramide Sensor by Single-molecule Photobleaching

Cabukusta B, Köhlen JA, Richter CP, You C, Holthuis JC
J. Biol. Chem. , 291(47):24735–24746 (2016)

Functional protein micropatterning for drug design and discovery

You, C, and Piehler, J
Expert opinion on drug discovery, 11, 105-119 (2016)

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling

You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J
Science advances, 2, e1600452 (2016)

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing

Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, Kaur P, Miao W, Gurgel G, You C, Piehler J, Kad NM, Riehn R, Opresko PL, Smith S, Tao YJ, Wang H.
Nucleic acids research, 44, 6363-6376 (2016)

Bioinspired monolithic polymer microsphere arrays as generically anti-adhesive surfaces

Eichler-Volf A, Kovalev A, Wedeking T, Gorb EV, Xue L, You C, Piehler J, Gorb SN, Steinhart M
Bioinspiration & biomimetics, 11, 025002 (2016)

Engineered Upconversion Nanoparticles for Resolving Protein Interactions inside Living Cells

Drees C, Raj AN, Kurre R, Busch KB, Haase M, Piehler J
Angew Chem Int Ed Engl, 55, 11668-11672 (2016)

Single molecule super-resolution imaging of proteins in living Salmonella enterica using self-labelling enzymes

Barlag B, Beutel O, Janning D, Czarniak F, Richter CP, Kommnick C, Göser V, Kurre R, Fabiani F, Erhardt M, Piehler J, Hensel M
Scientific reports, 6, 31601 (2016)

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis

Zech R, Kiontke S, Mueller U, Oeckinghaus A, Kümmel D
J. Biol. Chem., 291, 20008 (2016)

The N-terminus of the floral Arabidopsis TGA transcription factor PERIANTHIA mediates redox-sensitive DNA-binding

Gutsche N and Zachgo S
PlosOne, 29; 11(4):e0153810 (2016)