Center of Cellular Nanoanalytics Osnabrück

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Selected Publications


Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules

Niewidok, B et al.
J Cell Biol, 217, 1303-1318 (2018)

Stable and selective self-assembly of α-lipoic acid on Ge(001) for biomolecule immobilization

Kazmierczak, M et al.
Journal of Applied Physics, 123, 175305 (2018)

Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells

Etoc, F et al.
Nature materials, 17, 740-746 (2018)

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Chavent, M et al.
Nat Commun, 9, 2846 (2018)

Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials

Birkholz, O et al.
Nat Commun, 9, 1521 (2018)

Germanium Plasmon Enhanced Resonators for Label-Free Terahertz Protein Sensing

Bettenhausen, M et al.
Frequenz, 72, 113-122 (2018)

Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis

Bartoschik, T et al.
Scientific reports, 8, 4977 (2018)

A search for ceramide binding proteins using bifunctional lipid analogues yields CERT-related protein StarD7

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Müller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, and Holthuis JC
J. Lipid. Res., 59, 515-530 (2018)

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

Kunduri G, Turner-Evans D, Konya Y, Izumi Y, Nagashima K, Lockett S, Holthuis J, Bamba T, Acharya U, Acharya JK
Proc. Natl. Acad. Sci. USA 115, E8919-E8928 (2018)

Colloidal Crystals of NaYF4 Upconversion Nanocrystals Studied by Small-Angle X-Ray Scattering (SAXS)

Christian Homann, Joerg Bolze, Markus Haase
Part. Part. Syst. Charact. 1800391 (2018)

Colloidal LaPO4:Gd\(^{3+}\) nanocrystals: X-ray induced single line UV emission

Sara Espinoza, Thomas Juestel , Markus Haase
Nanoscale 10, 22533-22540 (2018)

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO4:Pr\(^{3+}\)

Sara Espinoza, Max-Fabian Volhard, Heike Kätker, Heike Jenneboer, Anne Uckelmann, Markus Haase, Matthias Müller, Martin Purschke, Thomas Jüstel
Part. Part. Syst. Charact. 1800282 (2018)

NaYF4:Yb,Er/NaYF4 core/shell nanocrystals with high upconversion luminescence quantum yield

Christian Homann, Lisa Krukewitt, Florian Frenzel, Bettina Grauel, Christian Würth, Ute Resch-Genger, Markus Haase
Angew. Chem. Int. Ed. 57, 8765–8769 (2018), DOI
Angew.Chem. 130, 8901–8905 (2018), DOI

Holographic performance of silicon polymer films based on photoswitchable molecules

Bourdon B, Bock S, Kijatkin C, Shumelyuk A, and Imlau M
Optical Material Express 8(7), 1951-1967 (2018)

Nonlinear Optical Potassium Niobate Nanocrystals as Harmonic Markers: The Role of Precursors and Stoichiometry in Hydrothermal Synthesis

Wang Z, Kijatkin C, Urban A, Haase M, Imlau M and Kömpe K
Nanoscale, 10, 10713-10720 (2018)


Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

Richter, D et al.
Nat Commun, 8, 15976 (2017)

Magnetic control of cellular processes using biofunctional nanoparticles

Monzel, C, Vicario, C, Piehler, J, Coppey, M, and Dahan, M
Chemical science, 8, 7330-7338 (2017)

Engineered Ferritin for Magnetogenetic Manipulation of Proteins and Organelles Inside Living Cells

Lisse, D et al.
Advanced materials, 29, 1700189 (2017)

Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling

Janda, CY et al.
Nature, 545, 234-237 (2017)

Binding of interferon reduces the force of unfolding for interferon receptor 1

Chuartzman, SG et al.
PLoS One, 12, e0175413 (2017)

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Arimoto, KI et al.
Nature structural & molecular biology, 24, 279-289 (2017)

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

Cabukusta B, Kol M, Kneller L, Hilderink A, Bickert A, Mina JG, Korneev S, and Holthuis JC
Sci. Rep. 7, 41290 (2017)

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

Jain A, Beutel O, Ebell K, Korneev S, and Holthuis JC
J. Cell Sci. 130, 360-371 (2017)

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JGM, Somerharju P, Korneev S, Tafesse FG, and Holthuis JC
J. Lipid Res. 58, 962-973 (2017)

Nonlinear Diffuse fs-Pulse Reflectometry of Harmonic Upconversion Nanoparticles

Kijatkin C, Eggert J, Bock S, Berben D, Oláh L, Szaller Z, Kis Z and Imlau M
Photonics, 4(1), 11 (2017)


Functional protein micropatterning for drug design and discovery

You, C, and Piehler, J
Expert opinion on drug discovery, 11, 105-119 (2016)

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling

You, C et al.
Science advances, 2, e1600452 (2016)

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing

Lin, J et al.
Nucleic acids research, 44, 6363-6376 (2016)

Bioinspired monolithic polymer microsphere arrays as generically anti-adhesive surfaces

Eichler-Volf, A et al.
Bioinspiration & biomimetics, 11, 025002 (2016)

Engineered Upconversion Nanoparticles for Resolving Protein Interactions inside Living Cells

Drees, C et al.
Angew Chem Int Ed Engl, 55, 11668-11672 (2016)

Single molecule super-resolution imaging of proteins in living Salmonella enterica using self-labelling enzymes

Barlag, B et al.
Scientific reports, 6, 31601 (2016)

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis

Zech R et al.
J. Biol. Chem., 291, 20008 (2016)

The N-terminus of the floral Arabidopsis TGA transcription factor PERIANTHIA mediates redox-sensitive DNA-binding

Gutsche N and Zachgo S
PlosOne, 29; 11(4):e0153810 (2016)


Receptor dimerization dynamics as regulatory valve for plasticity of type I interferon signaling

Wilmes, S et al.
J Cell Biol, 209, 579-593 (2015)

Spatiotemporally Controlled Reorganization of Signaling Complexes in the Plasma Membrane of Living Cells

Wedeking, T et al.
Small, 11, 5912-5918 (2015)

Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria

Rassam, P et al.
Nature, 523, 333-336 (2015)

Rupture of Stochastically Occurring Vesicle Clusters Limits Bilayer Formation on Alkane-PEG-Type Supports: Uncoupling Clustering from Surface Coverage

Peel, MJ et al.
Langmuir, 31, 8830-8840 (2015)

Clustering and dynamics of phototransducer signaling domains revealed by site-directed spin labeling electron paramagnetic resonance on SRII/HtrII in membranes and nanodiscs

Orban-Glass, I et al.
Sci Signal, 54, 349-362 (2015)

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

Moraga, I et al.
Sci Signal, 8, ra114 (2015)

Magnetogenetic control of protein gradients inside living cells with high spatial and temporal resolution

Etoc, F et al.
Nano Lett, 15, 3487-3494 (2015)

Two-Dimensional Trap for Ultrasensitive Quantification of Transient Protein Interactions

Beutel, O et al.
ACS nano, 9, 9783-9791 (2015)

Shuttling of PINK1 between Mitochondrial Microcompartments Resolved by Triple-Color Superresolution Microscopy

Beinlich, FR, Drees, C, Piehler, J, and Busch, KB
ACS Chem Biol, 10, 1970-1976 (2015)

Inner workings and biological impact of phospholipid flippases

Panatala R, Hennrich H, and Holthuis JC
J. Cell Sci. 128, 2021-2032 (2015)

Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport

Arlt H, Auffarth K, Kurre R, Lisse D, Piehler J & Ungermann C
Mol. Biol. Chem., 26(7), 1357-70 (2015)

Identification of Dck1 and Lmo1 as upstream regulators of the small GTPase Rho5 in Saccharomyces cerevisiae

Schmitz HP, Jendretzki A, Wittland J, Wiechert J, and Heinisch JJ
Mol Microbiol, DOI: 10.1111/mmi.12937 (2015) [Epub ahead of print]

Interference and holography with femtosecond laser pulses of different colours

Odoulov S, Shumelyuk A, Badorreck H, Nolte S, Voit K-M, and Imlau M
Nat Commun, 6, 5866 (2015)

Application of fluorescent nanoparticles to study remodeling of the endolysosomal system by intracellular bacteria

Zhang Y, Krieger V, and Hensel M
J Vis Exp, 95 (2015)

Ameliorated or Acquired Cytostatic/Cytotoxic Properties of Nucleosides by Lipophilization

Knies C, Bonaterra G, Hammerbacher K, Cordes A, Kinscherf R, and Rosemeyer* H
Chemistry Biodiv., 12, 1902 – 1944 (2015)

Single Cell GFP-Trap Reveals Stoichiometry and Dynamics of Cytosolic Protein Complexes

Wedeking T, Lochte S, Richter CP, Bhagawati M, Piehler J, You C
Nano Lett, 15, 3610-3615 (2015)

The GARP Complex Is Required for Cellular Sphingolipid Homeostasis

Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese, Jr. RV, Walther TC
eLife, 4:e08712 (2015)

Plant-specific CC-type glutaredoxins: functions in developmental processes and stress response

Gutsche N, Thurow C, Zachgo S, Gatz C
Biol Chem, 396, 495-509 (2015)


Dynamic submicroscopic signaling zones revealed by pair correlation tracking and localization microscopy

You, C, Richter, CP, Lochte, S, Wilmes, S, and Piehler, J
Anal Chem, 86, 8593-8602 (2014)

Multivalent chelators for spatially and temporally controlled protein functionalization

You, C, and Piehler, J
Anal Bioanal Chem, 406, 3345-3357 (2014)

Reconstituting functional microtubule-barrier interactions

Taberner, N et al
Methods in cell biology, 120, 69-90 (2014)

Rapid transfer of transmembrane proteins for single molecule dimerization assays in polymer-supported membranes

Roder, F, Wilmes, S, Richter, CP, and Piehler, J
ACS Chem Biol, 9, 2479-2484 (2014)

Spectroscopic techniques for monitoring protein interactions in living cells

Piehler, J
Curr Opin Struct Biol, 24, 54–62 (2014)

The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Müller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, and Holthuis JC
Journal of cell science, 127, 1043-1051 (2014)

High-fidelity protein targeting into membrane lipid microdomains in living cells

Beutel, O et al.
Angew Chem Int Ed Engl., 53, 1311-1315 (2014)

Lipid landscapes and pipelines in membrane homeostasis

Holthuis JC, and Menon AK
Nature 510, 48-57 (2014)

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis

Tafesse FG, Vacaru AM, Bosma EF, Hermansson M, Jain A, Hilderink A, Somerharju P, and Holthuis JC
J. Cell Sci. 127, 445-454 (2014)

Fat and fabulous: bifunctional lipids in the spotlight

Haberkant P, and Holthuis JC
Biochim Biophys Acta 1841, 1022-1030 (2014)

Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane

Löchte S, Waichman S, Beutel O, You C, and Piehler J
J Cell Biol, 207, 407-18 (2014)

Spatiotemporal computations of an excitable and plastic brain: neuronal plasticity leads to noise-robust and noise-constructive computations

Toutounji H, and Pipa G
PLoS Comput Biol, 10, e1003512 (2014)

Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons

Janning D, Igaev M, Sündermmann F, Brühmann J, Beutel O, Heinisch JJ, Bakota L, Piehler J, Junge W, and Brandt R
MBoC, 25, 3541-51 (2014)

Monofunctional stealth nanoparticle for unbiased single molecule tracking inside living cells

Lisse D, Richter CP, Drees C, Birkholz O, You C, Rampazzo E, and Piehler J
Nano Lett, 14, 2189-95 (2014)

Terminal Lipophilization of a Unique DNA Dodecamer by Various Nucleolipid Head Groups: Their Incorporation into Artificial Lipid Bilayers – Kinetics and Stability

Werz E and Rosemeyer H
Beilstein J. Org. Chem., 11, 913 – 929 (2014)

Incorporation of Lipophilic Single Strands with Different Nucleolipid Head Groups into an Artificial Lipid Bilayer

Werz E, Brending N, Könemann M, and Rosemeyer H
MPEG4 video, 2014-09-10, urn:nbn:de:gbv:700-2014091012807


In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids

Haberkant P1, Raijmakers R, Wildwater M, Sachsenheimer T, Brügger B, Maeda K, Houweling M, Gavin AC, Schultz C, van Meer G, Heck AJ, and Holthuis JC
ACS Chem Int Ed Engl, 52, 4033-8 (2013)

Electrostatically controlled quantum dot monofunctionalization for interrogating the dynamics of protein complexes in living cells

You C, Wilmes S, Richter CP, Beutel O, Liße D, and Piehler J
ACS Chem Biol, 15, 320-6 (2013)

Conformational heterogeneity of the aspartate transporter GltPh

Hänelt I, Wunnicke D, Bordignon E, Steinhoff HJ, and Slotboom DJ
Nature Structural & Molecular Biology, 20:210-4 (2013)


Nanoscale organization of mitochondrial microcompartments revealed by combining tracking and localization microscopy

Appelhans T, Richter CP, Wilkens V, Hess ST, Piehler J, and Busch KB
Nano Lett, 12, 610-6 (2012)

Orientation selective DEER measurements on vinculin tail at X-band frequencies reveal spin label orientations

Abé C, Klose D, Dietrich F, Ziegler WH, Polyhach Y, Jeschke G, and Steinhoff HJ
J Magn Reson, J Magn Reson 216, 53-61 (2012)

Triple-color super-resolution imaging of live cells: resolving submicroscopic receptor organization in the plasma membrane

Wilmes S, Staufenbiel M, Lisse D, Richter CP, Beutel O, Busch KB, Hess ST, and Piehler J
Angew Chem Int Ed Engl, Angew Chem Int Ed Engl 51, 4868-71 (2012)

Simulation vs. reality: a comparison of in silico distance predictions with DEER and FRET measurements

Klose D, Klare JP, Grohmann D, Kay CWM, Werner F, and Steinhoff, HJ
PLOS One, 7, e39492 (2012)

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex

Bröcker C, Kuhlee AC., kleine Balderhaar H, Hönscher C, Engelbrecht-Vandré S, Ungermann C*, Raunser S* (*co-corresponding)
PNAS, 109, 1991-1996 (2012)

A stable and accurate butterfly sparse Fourier transform

Kunis S and Melzer
SIAM J Numer Anal, 1777-1800 (2012)

An Electron Paramagnetic Resonance Spectroscopic Investigation on the Growth Mechanism of NaYF(4) :Gd Nanocrystals

Zech R et al.
Angew Chem Int Ed., 51, 26 (2012)

Triple-color super-resolution imaging of live cells: resolving submicroscopic receptor organization in the plasma membrane

Wilmes S, Staufenbiel M, Lisse D, Richter CP, Beutel O, Busch KB, Hess ST, and Piehler J
Angew Chem Int Ed Engl, 51:4868-4871 (2012)


HOPS drives vacuole fusion by binding the vacuolar SNARE complex and the Vam7 PX domain via two distinct sites

Krämer L, Ungermann C
Mol Biol Cell, 22, 2601-2611 (2011)

Upconverting nanoparticles

Haase M, Schäfer H
Angew Chem Int Ed Engl, 20, 5808-29 (2011)

A Bnr-like formin links actin to the spindle pole body during sporulation in the filamentous fungus Ashbya gossypii

Kemper M, Mohlzahn L, Lickfeld M, Lang C, Wählisch S, and Schmitz HP
Mol Microbiol, 10, 1276-1295 (2011)

Transfer entropy - a model-free measure of effective connectivity for the neurosciences

Vicente R, Wibral M, Lindner M, and Pipa G
J Compu Neurosci, 45-67 (2011)

Selective targeting of fluorescent nanoparticles to proteins inside live cells

Lisse D, Wilkens V, You C, Busch K, and Piehler J
Angew Chem Int Ed Engl, Angew Chem Int Ed Engl 50, 9352-5 (2011)

Functional dissection of SiiE, a giant non‐fimbrial adhesin of Salmonella enterica

Wagner C, Polke M, Gerlach RG, Linke D, Stierhof YD, Schwarz H, Hensel M
Cell Microbiol, 13, 1286-1301 (2011)

The ROXY1 C-terminal L**LL motif is essential for the interaction with TGA transcription factors

Li S, Gutsche N and Zachgo S
Plant Physiol., 157 (4), 2056-2068 (2011)

Two-Dimensional Trap for Ultrasensitive Quantification of Transient Protein Interactions

Beutel O, Roder F, Birkholz O, Rickert C, Steinhoff HJ, Grzybek M, Coskun U, and Piehler J
ACS nano, 9:9783-9791 (2011)

Selective targeting of fluorescent nanoparticles to proteins inside live cells

Lisse D, Wilkens V, You C, Busch K, and Piehler J
Angew Chem Int Ed Engl, 50:9352-9355 (2011)


Cellular interactions of biodegradable nanorod arrays prepared by nondestructive extraction from nanoporous alumina

Li S, Grimm S, Martín J, Rodriguez G, Fernández-Gutierrez M, Mathwig K, Wehrspohn RB, Gösele U, San Roman J, Mijangos C, Steinhart M
J Mater Chem, 20, 3171-3177 (2010)


Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana

Li S, Lauri A, Ziemann M, Busch A, Bhave M and Zachgo S
The Plant Cell, 21, 429-441 (2009)