Center of Cellular Nanoanalytics Osnabrück

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Selected Publications


Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

Stephan Wilmes, Maximillian Hafer, Joni Vuorio, Julie A. Tucker, Hauke Winkelmann, Sara Löchte, Tess A. Stanly, Katiuska D. Pulgar Prieto, Chetan Poojari, Vivek Sharma, Christian P. Richter, Rainer Kurre, Stevan R. Hubbard, K. Christopher Garcia, Ignacio Moraga, Ilpo Vattulainen, Ian S. Hitchcock, Jacob Piehler
Science 367(6478), 643-652 (2020)


ESEEM Reveals Bound Substrate Histidine in the ABC Transporter HisQMP\(_2\)

Isaev N, Heuveling J, Ivanisenko N, Schneider E, Steinhoff HJ
Applied Magnetic Resonance, 1-11 (2019)

Conformational dynamics of sensory rhodopsin II in nanolipoprotein and styrene-maleic acid lipid particles

Mosslehy W, Voskoboynikova N, Colbasevici A, Ricke A, Klose D, Klare JP, Mulkidzhanyan AY, Steinhoff HJ
Photochem Photobiol. (2019)

Proton leakage across lipid bilayers: Oxygen atoms of phospholipid ester linkers align water molecules into transmembrane water wires

Bozdaganyan ME, Lokhmatikov AV, Voskoboynikova N, Cherepanov DA, Steinhoff HJ, Shaitan KV, Mulkidjanian AY
BBA-Bioenergetics 1860(6), 439-451 (2019)

Styrene/Maleic Acid Copolymers Form SMALPs by Pulling Lipid Patches out of the Lipid Bilayer

Orekhov PS, Bozdaganyan ME, Voskoboynikova N, Mulkidjanian AY, Steinhoff HJ, Shaitan KV
Langmuir 35(10), 3748-3758 (2019)

Detergent-free solubilization of human Kv channels expressed in mammalian cells

Karlova MG, Voskoboynikova N, Gluhov GS, Abramochkin D, Malak OA, Mulkidzhanyan A, Loussouarn G, Steinhoff HJ, Shaitan KV, Sokolova OS
Chem Phys Lipids 219 (2019)

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

Kol M, Williams B, Toombs-Ruane H, et al.
Elife, 8:e43230 (2019)

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

Pekkinen M, Terhal PA, Botto LD, et al.
JCI Insight, 4(7):e126180 (2019)

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Dadsena S, Bockelmann S, Mina JGM, Hassan DG, Korneev S, Razzera G, Jahn H, Niekamp P, Müller D, Schneider M, Tafesse FG, Marrink SJ, Melo MN, Holthuis JCM
Nat Commun, 10(1), 1832 (2019)

A systematic approach to identify recycling endocytic cargo depending on the GARP complex

Eising S, Thiele L, Fröhlich F
eLife 8:e42837 (2019)


Single-molecule imaging reveals dynamic biphasic partition of RNA-binding proteins in stress granules

Niewidok, B et al.
J Cell Biol, 217, 1303-1318 (2018)

Stable and selective self-assembly of α-lipoic acid on Ge(001) for biomolecule immobilization

Kazmierczak, M et al.
Journal of Applied Physics, 123, 175305 (2018)

Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells

Etoc, F et al.
Nature materials, 17, 740-746 (2018)

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Chavent, M et al.
Nat Commun, 9, 2846 (2018)

Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials

Birkholz, O et al.
Nat Commun, 9, 1521 (2018)

Germanium Plasmon Enhanced Resonators for Label-Free Terahertz Protein Sensing

Bettenhausen, M et al.
Frequenz, 72, 113-122 (2018)

Near-native, site-specific and purification-free protein labeling for quantitative protein interaction analysis by MicroScale Thermophoresis

Bartoschik, T et al.
Scientific reports, 8, 4977 (2018)

A search for ceramide binding proteins using bifunctional lipid analogues yields CERT-related protein StarD7

Bockelmann S, Mina JGM, Korneev S, Hassan DG, Müller D, Hilderink A, Vlieg HC, Raijmakers R, Heck AJR, Haberkant P, and Holthuis JC
J. Lipid. Res., 59, 515-530 (2018)

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

Kunduri G, Turner-Evans D, Konya Y, Izumi Y, Nagashima K, Lockett S, Holthuis J, Bamba T, Acharya U, Acharya JK
Proc. Natl. Acad. Sci. USA 115, E8919-E8928 (2018)

Colloidal Crystals of NaYF4 Upconversion Nanocrystals Studied by Small-Angle X-Ray Scattering (SAXS)

Christian Homann, Joerg Bolze, Markus Haase
Part. Part. Syst. Charact. 1800391 (2018)

Colloidal LaPO4:Gd\(^{3+}\) nanocrystals: X-ray induced single line UV emission

Sara Espinoza, Thomas Juestel , Markus Haase
Nanoscale 10, 22533-22540 (2018)

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO4:Pr\(^{3+}\)

Sara Espinoza, Max-Fabian Volhard, Heike Kätker, Heike Jenneboer, Anne Uckelmann, Markus Haase, Matthias Müller, Martin Purschke, Thomas Jüstel
Part. Part. Syst. Charact. 1800282 (2018)

NaYF4:Yb,Er/NaYF4 core/shell nanocrystals with high upconversion luminescence quantum yield

Christian Homann, Lisa Krukewitt, Florian Frenzel, Bettina Grauel, Christian Würth, Ute Resch-Genger, Markus Haase
Angew. Chem. Int. Ed. 57, 8765–8769 (2018), DOI
Angew.Chem. 130, 8901–8905 (2018), DOI

Holographic performance of silicon polymer films based on photoswitchable molecules

Bourdon B, Bock S, Kijatkin C, Shumelyuk A, and Imlau M
Optical Material Express 8(7), 1951-1967 (2018)

Nonlinear Optical Potassium Niobate Nanocrystals as Harmonic Markers: The Role of Precursors and Stoichiometry in Hydrothermal Synthesis

Wang Z, Kijatkin C, Urban A, Haase M, Imlau M and Kömpe K
Nanoscale, 10, 10713-10720 (2018)


Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

Richter, D et al.
Nat Commun, 8, 15976 (2017)

Magnetic control of cellular processes using biofunctional nanoparticles

Monzel, C, Vicario, C, Piehler, J, Coppey, M, and Dahan, M
Chemical science, 8, 7330-7338 (2017)

Engineered Ferritin for Magnetogenetic Manipulation of Proteins and Organelles Inside Living Cells

Lisse, D et al.
Advanced materials, 29, 1700189 (2017)

Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling

Janda, CY et al.
Nature, 545, 234-237 (2017)

Binding of interferon reduces the force of unfolding for interferon receptor 1

Chuartzman, SG et al.
PLoS One, 12, e0175413 (2017)

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

Arimoto, KI et al.
Nature structural & molecular biology, 24, 279-289 (2017)

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

Cabukusta B, Kol M, Kneller L, Hilderink A, Bickert A, Mina JG, Korneev S, and Holthuis JC
Sci. Rep. 7, 41290 (2017)

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis

Jain A, Beutel O, Ebell K, Korneev S, and Holthuis JC
J. Cell Sci. 130, 360-371 (2017)

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

Kol M, Panatala R, Nordmann M, Swart L, van Suijlekom L, Cabukusta B, Hilderink A, Grabietz T, Mina JGM, Somerharju P, Korneev S, Tafesse FG, and Holthuis JC
J. Lipid Res. 58, 962-973 (2017)

Nonlinear Diffuse fs-Pulse Reflectometry of Harmonic Upconversion Nanoparticles

Kijatkin C, Eggert J, Bock S, Berben D, Oláh L, Szaller Z, Kis Z and Imlau M
Photonics, 4(1), 11 (2017)


Monitoring Changes in the Oligomeric State of a Candidate Endoplasmic Reticulum (ER) Ceramide Sensor by Single-molecule Photobleaching

Cabukusta B, Köhlen JA, Richter CP, You C, Holthuis JC
J. Biol. Chem. , 291(47):24735–24746 (2016)

Functional protein micropatterning for drug design and discovery

You, C, and Piehler, J
Expert opinion on drug discovery, 11, 105-119 (2016)

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling

You, C et al.
Science advances, 2, e1600452 (2016)

Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing

Lin, J et al.
Nucleic acids research, 44, 6363-6376 (2016)

Bioinspired monolithic polymer microsphere arrays as generically anti-adhesive surfaces

Eichler-Volf, A et al.
Bioinspiration & biomimetics, 11, 025002 (2016)

Engineered Upconversion Nanoparticles for Resolving Protein Interactions inside Living Cells

Drees, C et al.
Angew Chem Int Ed Engl, 55, 11668-11672 (2016)

Single molecule super-resolution imaging of proteins in living Salmonella enterica using self-labelling enzymes

Barlag, B et al.
Scientific reports, 6, 31601 (2016)

Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis

Zech R et al.
J. Biol. Chem., 291, 20008 (2016)

The N-terminus of the floral Arabidopsis TGA transcription factor PERIANTHIA mediates redox-sensitive DNA-binding

Gutsche N and Zachgo S
PlosOne, 29; 11(4):e0153810 (2016)